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Journal of Clinical Endocrinology & Metabolism, Vol 40, 1073-1077, Copyright © 1975 by Endocrine Society


ARTICLES

In vitro determination of relative corticosteroid potency

HL Cantrill, SR Waltman, PF Palmberg, HA Zink and B Becker

The corticosteroid concentration required to inhibit phytohemagglutinin stimulated human lymphocyte transformation by 50% was determined for three corticosteroids. The relative potency of hydrocortisone, prednisolone and dexamethasone determined in 16 patients was 1.00, 2.43, and 24.7 respectively. This assay is proposed as an objective tool for comparison of relative corticosteroid potency in man.


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