Journal of Clinical Endocrinology & Metabolism, Vol 40, 895-900, Copyright © 1975 by Endocrine Society
A simple specific assay for estriol in maternal urine
SE Davis and DL Loriaux
In medical centers with many high risk pregnancies, the ability to perform
a large number of urinary estriol measurements is required. The analytical
procedure should provide simplicity, specificity, and economy. A solid
phase radioimmunoassay is presented which utilizes antibody generated
against an estriol 16-glucuronide-bovine serum albumin conjugate. The assay
allows analysis of the principal component of maternal urinary estriol
without hydrolysis or purification, with adequate specificity and the
capacity for processing large numbers of samples.