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Journal of Clinical Endocrinology & Metabolism, Vol 40, 830-833, Copyright © 1975 by Endocrine Society

ARTICLES

The effect of lergotrile on galactorrhea and gonadotropin secretion

RE Cleary, R Crabtree and L Lemberger

Lergotrile (Compound 83636), a specific inhibitor of prolactin release, was administered to 5 women with galactorrhea. Only 1 of the 5 had an elevated serum prolactin (hPRL) value, but Compound 83636 induced a decrease in serum hPRL in all cases. All patients had cessation of breast secretion within 72 days after initiation of lergotrile. LRH administration (100 pg) evoked a variable gonadotropin response before and during treatment with the ergot alkaloid. By contrast, serum prolactin values remained essentially unaltered after injection of LRH under the same conditions.


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L Lemberger and R. Crabtree
Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist
Science, September 14, 1979; 205(4411): 1151 - 1153.
[Abstract] [PDF]


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Copyright © 1975 by The Endocrine Society