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Journal of Clinical Endocrinology & Metabolism, Vol 40, 688-696, Copyright © 1975 by Endocrine Society

ARTICLES

The effect of melatonin on steroidogenesis by the human ovary in vitro

AA MacPhee, FE Cole and BF Rice

Melatonin stimulated steroidogenesis in two compartments of the human ovary in vitro. In a corpus luteum of the menstrual cycle, melatonin increased progesterone synthesis in a dose related manner. Both serotonin and N-acetyl serotonin had no effect on progesterone synthesis. In the ovarian stroma, melatonin stimulated the incorporation of acetate-1-14-C into androstenedione. Binding of radioactive hCG by the corpus luteum was unaffected by melatonin. No specific binding of radioactive melatonin of low specific activity could be detected in homogenates of a human corpus luteum. These observations suggest that melatonin may directly modulate steroidogenesis in the human ovary.


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L Tamarkin, C. Baird, and O. Almeida
Melatonin: a coordinating signal for mammalian reproduction?
Science, February 15, 1985; 227(4688): 714 - 720.
[Abstract] [PDF]


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