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Journal of Clinical Endocrinology & Metabolism, Vol 40, 526-529, Copyright © 1975 by Endocrine Society

ARTICLES

Plasma glucagon and alanine responses to acute insulin deficiency in man

JE Gerich, E Tsalikian, M Lorenzi, JH Karam and DM Bier

Plasma glucagon levels rose within 1 hr after withdrawal of insulin in 7 juvenile-type diabetics previously kept normoglycemic by prolonged intravenous infusions of insulin. These changes preceded subsequent elevations in plasma alanine levels. Individual rises in plasma glucagon were correlated with elevations in plasma glucose, beta- hydroxybutyrate, free fatty acid, and glycerol levels, suggesting that glucagon may play an important role in the development of diabetic ketoacidosis in man.


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[Abstract] [Full Text] [PDF]


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