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Journal of Clinical Endocrinology & Metabolism, Vol 40, 516-518, Copyright © 1975 by Endocrine Society

ARTICLES

Growth hormone release after synthetic 1-24 ACTH: effects of estrogen and sex

MR Stjernholm, RN Alsever and P Beck

Recent reports have demonstrated that growth hormone (GH) is inconsistently released after intravenous administration of synthetic 1- 24 ACTH. This study was designed to evaluate the role of estrogens in mediating this response. 250 mug of synthetic 1-24 ACTH were administered to 8 men in 12 studies and 6 women in 11 studies. None of the men exhibited a rise in GH after 1-24 ACTH, while the women exhibited a significant increase. Pretreatment of 5 of these men with 100 mug of ethinyl estradiol daily for 3 days did not alter GH response from the initial studies. Pretreatment with 10 mg of diethylstilbesterol daily for 3 days, however, resulted in a rise in GH which was similar to the female group. It is concluded that the variable GH responses to synthetic 1-24 ACTH may be in part due to prevailing concentrations of sex steroids and their effect on the hypothalamic-pituitary GH release mechanism.


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