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Journal of Clinical Endocrinology & Metabolism, Vol 40, 478-481, Copyright © 1975 by Endocrine Society

ARTICLES

Role of adrenergic stimuli in parathyroid hormone secretion in man

SC Kukreja, GK Hargis, EN Bowser, WJ Henderson, EW Fisherman and GA Williams

The role of adrenergic stimuli in the secretion of parathyroid hormone (PTH) in man was evaluated. Intradermal injections of isoproterenol, 0.15 mg, or epinephrine, 0.3 mg, caused significant prompt increases in serum PTH levels. These increases were not accompanied by any changes in serum calcium (Ca) during the period of observation. Phenylephrine, 1.5 mg, intradermally, did not cause any significant changes in serum PTH or serum Ca. Propranolol infusion alone significantly inhibited the basal secretion of PTH. This inhibition by propranolol was overcome by isoproterenol administration. The results indicate that 1) beta adrenergic agents increase PTH secretion whereas alpha adrenergic agents have no effect, 2) beta adrenergic stimuli probably play an important physiological role in basal PTH secretion in man.


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C. P. Schmitt, J. Obry, R. Feneberg, J. D. Veldhuis, O. Mehls, E. Ritz, and F. Schaefer
{beta}1-Adrenergic Blockade Augments Pulsatile PTH Secretion in Humans
J. Am. Soc. Nephrol., December 1, 2003; 14(12): 3245 - 3250.
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