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Journal of Clinical Endocrinology & Metabolism, Vol 40, 406-408, Copyright © 1975 by Endocrine Society

ARTICLES

The excretion of 2-hydroxyestrone during the menstrual cycle

P Ball, HP Gelbke and R Knuppen

A double isotope derivative determination technique was developed to investigate the excretion of 2-hydroxyestrone inhuman menstrual cycle. The method is highly specific, accurate and precise within the range of 0.2-20 nmol 2-hydroxyestrone/20ml of urine. The amounts of 2- hydroxyestrone excreted during menstrual cycle varied between 10 (proliferation phase) and 60 mug/24 h urine (ovulatory peak), which is comparable to that of estriol, supposed hitherto to be the main excretion product of estrogen metabolism.


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J Fishman and D Tulchinsky
Suppression of prolactin secretion in normal young women by 2-hydroxyestrone
Science, October 3, 1980; 210(4465): 73 - 74.
[Abstract] [PDF]


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Copyright © 1975 by The Endocrine Society