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Parathyropituitary Syndrome in Pituitary Eosinophilism¹

THE SIMULTANEOUS occurrence of pituitary disorders and irregularities in calcium metabolism resulting from hyperparathyroidism is frequent enough to warrant close scrutiny and analysis. In an earlier paper (1), abnormal parathyropituitary symptomcomplexes were visualized in two categories:

1. A) Hyperparathyroidism coincidental with eosinophilic hyperpituitarism; and
   
2. B) Hyperparathyroidism in hyperpituitarism of the basophil variety.³
   

THE PARATHYROPITUITARY SYNDROME AS IT MAY APPEAR IN ACROMEGALY: Erdheim, 1903 (2), reported a case of acromegaly in a 42-year-old male whose pituitary body was greatly enlarged and presented a microscopic picture of adenomatous growth. In addition to the pituitary adenoma, the same case presented eccentric hypertrophy of the left ventricle with aortic valvular insufficiency, stasis of the organs, plus a form of polyglandular syndrome which included a struma colloides diffusa, an extensive pancreatic necrosis, and three parathyroid bodies of unusual size (four found and identified). No particular mention was made of the kidneys.

¹ The data in this paper were taken from the dissertation submitted by the author in partial fulfillment of the requirements for the degree of Doctor of Medicine (privately printed under the auspices of the Institut d'Anatomie Pathologique, UNIVERSITE DE GENEVE, Imprimerie Franco-Suisse, Ambilly, France, May 1942). Some of the material from this thesis was subsequently published under the authorship of E. Rutishauser (15), with the statement: "Die Arbeit erscheint ausführlich als Diss. Genf von R. M. Perlman(n), 1942", The author wishes to record his grateful appreciation to Prof. Rutishauser for giving him the opportunity to carry out this work.

² Now Assistant Surgeon (R), U. S. Public Health Service, U. S. Quarantine Station. Foot of Hyde Street, San Francisco, 9, California.