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Effect of Synthetic Luteinizing Hormone-Releasing Hormone (LH-RH) on the Release of Gonadotropins in Hypophyso-Gonadal Disorders of Children and Adolescents. V. Agonadism

^* Centre d'Etudes sur la Croissance et l'Endocrinologie de l'Enfant, Hôpital Saint-Vincent de Paul Paris 14°, France
^** Fondation de Recherche en Hormonologie 94260 Fresnes, France

Serum gonadotropins (LH and FSH) have been assayed in 24 agonadal patients (10 children up to 11 yr and 14 adolescents aged 12 to 19 yr). The effects of synthetic luteinizing hormonereleasing hormone (LH-RH) on serum LH and FSH have been evaluated in 14 of them. In all agonadal patients aged 12 yr or more, serum LH and FSH and response to LH-RH were increased to very high levels. In agonadal children up to 11 yr, mean serum gonadotropins and response to LH-RH were significantly less increased, with large individual variations, and an apparent decline in the 10–11-yr age group. These facts demonstrate that the change of the hypothalamo-pituitary gonadotropic regulation which occurs at the beginning of adolescence can not be related to the effect of gonadal steroids. It may be questioned if nongonadal steroids and/or other factor(s) influence the adolescent change of gonadotropic control.

Supported by INSERM (Contract nos. 71.4091 and 73.4.493.22).

Received October 8, 1973.

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