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Observations on the Cortisol Content of Human Adrenal Venous Blood

The Departments of Medicine and Radiology, The Mount Sinai Hospital, Mount Sinai School of Medicine of The City University of New York New York
Department of Medical Computer Sciences, the State University of New York, Downstate Medical Center Brooklyn, New York

Requests for reprints should be addressed to: Giorgio Nicolis, M.D., Ph.D., Department of Medicine, The Mount Sinai Hospital, 1 East 100th Street, New York, NY 10029.

Cortisol levels in 101 blood samples obtained during diagnostic adrenal venography from 62 patients, ranged from 0 to 1700 µg/100 ml. The cortisol levels in the two contralateral adrenal veins of 34 patients without cortisol producing tumors differed on average by 3-fold. The adrenal cortisol levels of 20 patients with Cushing's syndrome were not significantly elevated. This was at least in part explained by the fact that their adrenal blood flow was increased. In 8 patients serial adrenal blood samples were obtained during periods of up to 30 min.

Supported by Grants HD-02764, RR-00071 and RR-00291 from the USPHS, and by grants from the Edmond de Rothschild and the Beir Foundations. Dr. Nicolis is a Senior Investigator of the New York Heart Association.

Received August 24, 1973.

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