This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by MENON, K. M. J. Articles by JAFFE, R. B. Search for Related Content PubMed PubMed Citation Articles by MENON, K. M. J. Articles by JAFFE, R. B.

Chorionic Gonadotropin-Sensitive Adenylate Cyclase in Human Term Placenta

Reproductive Endocrinology Program, Department of Obstetrics and Gynecology, The University of Michigan Medical Center Ann Arbor, Michigan 48104

Adenylate cyclase activity in a homogenate and washed particles of human term placenta proceeded maximally in the presence of 17 mM Mg²⁺ and 7.0 mM F^– ion. The requirements for Mg²⁺ can be substituted by Mn²⁺, but not by other metal ions. Adenylate cyclase activity was not stimulated in vitro in a homogenate preparation by the addition of hCG. However, using a minced placental preparation, hCG stimulated the incorporation of ¹⁴C-adenine into ¹⁴C-cyclic AMP. The stimulatory effect of hCG on placental cyclic AMP formation was concentration dependent and specific. These experiments suggest that hCG may have a cyclic AMP-mediated role in placental function.

Received December 11, 1972.

This article has been cited by other articles:

				Z.M. Lei, M. Yang, X. Li, O. Takikawa, and C.V. Rao Upregulation of Placental Indoleamine 2,3-Dioxygenase by Human Chorionic Gonadotropin Biol Reprod, April 1, 2007; 76(4): 639 - 644. [Abstract] [Full Text] [PDF]

				M. Yang, Z. M. Lei, and Ch. V. Rao The Central Role of Human Chorionic Gonadotropin in the Formation of Human Placental Syncytium Endocrinology, March 1, 2003; 144(3): 1108 - 1120. [Abstract] [Full Text] [PDF]

				F Petraglia, P Sawchenko, A. Lim, J Rivier, and W Vale Localization, secretion, and action of inhibin in human placenta Science, July 10, 1987; 237(4811): 187 - 189. [Abstract] [PDF]