This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by BANGHAM, D. R. Articles by WIDE, L. Search for Related Content PubMed PubMed Citation Articles by BANGHAM, D. R. Articles by WIDE, L.

An International Collaborative Study of 69/104, a Reference Preparation of Human Pituitary FSH and LH

¹ Division of Biological Standards, National Institute for Medical Research Mill Hill, London, N.W.7. 1AA, England
² Statistical Services Section, National Institute for Medical Research Mill Hill, London, N.W.7. 1AA, England,
³ Medical Research Centre, Prince Henry's Hospital Melbourne, Australia
⁴ Medical Research Council, Clinical Endocrinology Unit, Forrest Road Edinburgh, Scotland
⁵ University of Michigan Ann Arbor, Michigan
⁶ Woodruff Medical Center, Emory University Atlanta, Georgia
⁷ Medical Research Institute Worcester, Massachusetts
⁸ Mayo Clinic Rochester, Minnesota
⁹ University Hospital Uppsala, Sweden

A report of the preparation, ampouling and collaborative study by bioassay and by radioimmunoassay to calibrate and assess the stability of human pituitary FSH and LH reference preparation 69/104 which is available as ampoules each containing identical amounts of an extract (of human pituitary FSH and LH) derived from the National Pituitary Agency preparation LER-907. On the basis of the bioassays reported, preparation 69/104 has been assigned a potency of 10 IU FSH and 25 IU LH per ampoule and it has been recommended that 69/104 be used as a standard for bioassay comparisons with comparable pituitary extracts (Ada Endocrinologica 71: 625-637, 1972). It is unsuitable for use as a standard for inter-laboratory comparisons by radioimmunoassay except with assay systems demonstrated to be specific for one hormone only.

Received May 8, 1972.

This article has been cited by other articles:

				P. Doerr, K. M. Pirke, G. Kockott, and F. Dittmar Further Studies on Sex Hormones in Male Homosexuals Arch Gen Psychiatry, May 1, 1976; 33(5): 611 - 614. [Abstract] [PDF]