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Heparin Administration Appears to Decrease Cellular Binding of Thyroxine

Endocrine Research Laboratory, Division of Endocrinology, Department of Medicine, Montefiore Hospital and Medical Center and the Albert Einstein College of Medicine Bronx, New York 10467

Heparin administered to 8 patients undergoing hemodialysis for chronic renal disease resulted in a decrease in plasma protein binding of thyroxine (T₄), in confirmation of the report by Schatz et al. (J Clin Endocrinol 29: 1015, 1969). Despite this, there was no apparent shift of labeled T⁴ from plasma protein to the rapidly exchangeable cellular compartment. Since the partition of T⁴ between plasma proteins and cells is determined by the balance between plasma protein and cellular binding, these observations suggest that heparin administered in vivo reduces cellular as well as plasma protein binding.

^* Fellows in Endocrinology, Montefiore Hospital and Medical Center.

Supported by USPHS Grant 9 R01-AM-1S421-12 and U.S. Army Contract DA-49-193-MD-2967.

Received September 6, 1972.

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