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Relative Insensitivity of Rhesus Monkeys to the LH-Releasing Hormone (LH-RH)

Department of Medicine, Tulane University School of Medicine; Delta Regional Primate Center, and Endocrine and Poly pep tide Laboratories, VA Hospital New Orleans, Louisiana

Natural and synthetic LH-RH was administered to rhesus monkeys at various stages of the menstrual cycle and to one ovariectomized monkey with or without pretreatment with estrogen. Intravenous injection of LH-RH in doses which caused a consistent elevation of peripheral LH in other species including man only occasionally increased serum LH in monkeys. These data suggest a relative insensitiveness of the rhesus monkey to exogenously administered LH-RH.

Supported by USPHS Grants AM-09094 (A.A.), AM-07467 (A.V.S.) NICHD Contract 69-2212 (H.G.S.) and the Population Council, New York.

^* Present address: Oregon Regional Primate Research Center.

Received June 21, 1972.