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Pulsatile Patterns of Gonadotropins and Testosterone in Man: The Effects of Clomiphene with and Without Testosterone¹

Department of Obstetrics and Gynecology, School of Medicine, University of California San Diego, La Jolla, California 92037

Reprint requests from F. Naftolin, Boston Hospital for Women, 221 Longwood Ave., Boston, Massachusetts 02115.

Unstable patterns of serum LH, FSH, and T concentration were demonstrated during frequent interval sampling in 4 normal men. No consistent relationship of T levels to the onset of LH rises could be seen. However, onethird of the LH peaks was followed by a rise in T levels and each T elevation was preceded by an LH peak.

The frequency of release and half-times of disappearance for LH and FSH did not change during clomiphene treatment in 2 of these normal subjects (100 mg/day); elevated serum gonadotropins resulted from an increased magnitude of release per pulse. A similar exaggeration of T secretion was seen. Testosterone propionate injection (25 mg) on day 4 of clomiphene treatment further elevated circulating T levels without lowering serum gonadotropins.

¹ This work was supported by a grant from the Rockefeller Foundation (RF70029).

Received April 14, 1972.

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