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Effects of Chronic Methadone Administration on the Hypothalamic-Pituitary-Thyroid Axis

Endocrine Division, Department of Medicine, New York University School of Medicine New York, N.Y.

Address reprint requests to Dr. L. Shenkman, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016.

Pituitary and thyroidal response to the iv administration of thyrotropin releasing hormone was assessed in 8 subjects on chronic methadone therapy. All subjects showed a normal rise of thyrotropin and triiodothyronine, suggesting that the hypothalamic-pituitary-thyroidal axis is intact.

Supported by USPHS Grants 1 FO3 AM-5156-01, 2 ROI-AM 14314-0-, 03 and Fr 96.

Received February 7, 1972.