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The Metabolism of Estrone Sulfate in Normal Males

Worcester Foundation for Experimental Biology Shrewsbury, Massachusetts 01545

The metabolism of estrone sulfate has been studied in normal, young males by single injections of 6,7-³H-estrone sulfate (9 subjects); by constant infusions of 6,7-³H-estrone sulfate (8 subjects), 6,7-³H-estrone (5 subjects), and 6,7-³H-estradiol (5 subjects); and by the measurement of the concentration of radioactivity in plasma as estrone sulfate, estrone, and estradiol.

The disappearance of radioactivity as estrone sulfate following the single injections of 6,7-³H-estrone sulfate can be described as a function which is the sum of two exponentials. The initial rapid component (T = 3 min) represents spread into and transfer from a space, with a volume of 7.2 rh 0.6 (SE) L. The mean value for the rate constant of total removal (reversible and irreversible) from this space is 266 ± 2 7 (SE) units/day of which 11.1 ± 2.4 (SE) % is irreversible. The mean metabolic clearance rate (MCR R) is 105 ± 20 (SE) L/day/m²

Using the constant infusion technique the mean MCR^r is 80 ± 10 (SE) L/day/m². The overall mean MCR of estrone sulfate is 90 ± 10 (SE) L/day/m².

The mean transfer constant or fraction of ³H-estrone sulfate infused which is measured as estrone in the blood is 0.15 with 95% confidence limits of 0.12 to 0.18. In the two subjects in whom ³H-estradiol was measured the was 0.022 and 0.044.

For the infusion of ³H-estrone and ³H-estradiol the mean and (95% confidence limits) were 0.40 (0.21 to 0.81) and 0.42 (0.30 to 0.58).

Using the available data for and []BB values, it is probable that most of the estrone sulfate entering the blood each day does so as a result of conversion from the free estrogens and little, if any, arises as a result of direct secretion.

This work was supported by USPHS Grant AM-11252.

A portion of this work was presented at the 53rd Meeting of the Endocrine Society, San Francisco, Calif., 1971.

Received July 20, 1971.

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