The Department of Human Genetics, University of Michigan Medical School Ann Arbor, Michigan
The familial incidence and distribution of hirsutism and otherrelated symptoms have been ascertained in 90 females rangingin age from 15 to 45, in their first degree relatives (mothersand sisters), and in a control group. On clinical grounds, patientswere placed in 3 categories: ovarian, adrenal and "idiopathic"hirsutism. A method was elaborated for semiquantitative estimationof the occurrence of "unusual" body hair for women and of symptomsof endocrine dysfunction. The pattern of distribution of hirsutismresembles that of a continuous one, suggesting a gradient traitranging from the normal female to the abnormally hirsute. Asignificant familial aggregation of hirsutism was found andpropositi with their relatives constituted a different populationthan controls in regard to hirsutism. This result along withthe intermediacy of scores in relatives set the basis for agenetic etiology, a multifactorial pattern of inheritance beinga plausible one. In hirsute women an association with varyingdegrees of endocrine dysfunction was constantly observed. Thedistribution of the scores for endocrine symptoms was parallelto that of hirsutism.
1Present address: Department of Internal Medicine, Section ofEndocrinology, Faculty of Medicine, University of Navarra, Pamplona,Spain.
This investigation was performed during the tenure of a fellowshipfrom the Spanish private foundation "Juan March" for medicalresearch.
Received June 9, 1969.
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