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Mechanism of Chlorpropamide Antidiuresis in Diabetes Insipidus

Metabolic Research Unit, University of California Medical Center San Francisco, California 94122
Department of Medicine, University of California Medical Center San Francisco, California 94122

In order to elucidate the mechanism of chlorpropamide antidiuresis in patients with diabetes insipidus, 4 patients were studied. Measurements of the half-life and effectiveness of a moderately large dose of antidiuretic hormone were performed during control and treatment periods. No changes in half-life or effectiveness were noted. It is suggested that chlorpropamide augments posterior pituitary release and synthesis of antidiuretic hormone, permitting osmolal control to be re-established in patients with diabetes insipidus. Chlorpropamide may affect similar intracellular mechanisms in both the beta cell and the supraoptic neuron.

Received June 23, 1970.

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