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Bilateral Carcinoma of the Breast in a Patient with Klinefelter's Syndrome

Departments of Surgery and Pathology, Baltimore City Hospitals Baltimore, Maryland

A case of a 69-yr-old Negro male displaying bilateral carcinoma of the breast and Klinefelter's syndrome (XXY configuration) is presented. The patient had normal urinary estrogen excretion, decreased 17-ketosteroid excretion, normal 17-hydroxycorticosteroid excretion, and increased gonadotropin excretion. Chromosomal studies and autopsy findings are included in the report.

¹ Reprint requests to Martin C. Robson, CPT, MC, General Surgery Service, Brooke General Hospital, Brooke Army Medical Center, Fort Sam Houston, Texas 78234.

² Present address: Dept of Thoracic Surgery, Louis University School of Medicine, St. Louis, Mo.

Received November 9, 1967.

Accepted February 21, 1968.