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Adrenocortical Function in Stein-Leventhal Syndrome

Medical Unit, Welsh National School of Medicine Cardiff, Wales

Adrenal function was assessed in 6 patients with Stein-Leventhal syndrome. Resting values for urinary 17-hydroxycorticosteroids or ketogenic steroids were increased in 2 patients and an excessive response to repeated injections of corticotrophin was recorded in 4 patients. In 3 of these patients the response to corticotrophin was greatly reduced after wedge resection of the ovaries. Dexamethasone suppression was normal in each case. An increase in endogenous production of corticotrophin may accompany excessive secretion of gonadotrophins in this syndrome.

Received May 8, 1968.

Accepted August 27, 1968.