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Journal of Clinical Endocrinology & Metabolism Vol. 27, No. 5 648-654
doi:10.1210/jcem-27-5-648
Copyright © 1967 by the Endocrine Society.
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Plasma Estriol Levels During Normal Spontaneous Labor and Labor Induced by Oxytocin Infusion

RAPHAEL JEWELEWICZ1 and MORTIMER LEVITZ2

Department of Obstetrics and Gynecology, New York University School of Medicine
Obstetrical and Gynecological Service, Bellevue Hospital New York, New York 10016

Plasma estriol levels during normal labor and labor induced by oxytocin infusion were determined by a method developed in this laboratory and the results were compared. In the first category of 18 women who delivered spontaneously the plasma estriol concentrations remained constant in 15 cases, rose in 2 and decreased in 1. In the second category of 14 women in whom labor was induced electively by intravenous oxytocin infusion, the plasma estriol levels rose significantly (average rise =71%) in 8 cases, remained unchanged in 5 cases and decreased in 1 case. The difference between the 2 categories is significant at the 5% level. The origin of the increased plasma estriol in labor is not known but some theoretical possibilities relating oxytocin to estriol are discussed.

This investigation was supported in part by USPHS Research Grant CA-02071-13 from the National Cancer Institute and Grant P-206G from the American Cancer Society.

1 USPHS Training Grant 5 TI-HD-11-05 of the National Institute of Child Health and Human Development.

2 Research Career Development Awardee, K3-HD-18,422-04, of the National Institute of Child Health and Human Development.

Received October 31, 1966.

Accepted January 17, 1967.






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Copyright © 1967 by The Endocrine Society