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Pregnancy and Primary Aldosteronism

Medical Services, San Francisco General Hospital, University of California School of Medicine San Francisco, California 94110

A case is reported of a 32-yr-old woman with primary aldosteronism in whom metabolic and blood pressure abnormalities were improved during pregnancy. Aldosterone secretion increased throughout pregnancy, as did the acid-labile conjugate of aldosterone-tetrahydroaldosterone ratio, but no complications occurred. After delivery of a normal baby, secretion of aldosterone fell to previously high levels and mild labile hypertension and hypokalemic alkalosis were again present.

Supported by Grant AM-06415 from the National Institute of Arthritis and Metabolic Diseases, USPHS, and performed in the General Clinical Research Center, FR-83, at San Francisco General Hospital.

Received March 23, 1967.

Accepted August 1, 1967.