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Biological Properties of the Urinary Gonadotropin Inhibitor

Endocrine Unit, University of Liverpool, Liverpool Clinic Liverpool 7, England

The existence of a thermostable gonadotropin inhibitory substance in kaolin extracts of pooled male urine has been confirmed. The assay was conducted in immature female mice using the uterine weight increase that follows injection of chorionic gonadotropin (HCG). The extracts also caused inhibition of mitotic activity in the mouse epidermis and in the liver regenerating after partial hepatectomy. Fractions obtained by gel filtration of the extract showed roughly parallel activities when tested for antigonadotropic and antiliver growth activity. In view of the action of the substance on other organs, it is concluded that a specific physiologic role in controlling ovarian function is unlikely.

Received May 2, 1966.

Accepted July 7, 1966.