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Unusual Case of Adrenocortical Hyperfunction

Kliniek voor Inwendige Geneeskunde en Laboratorium voor Experimentele Geneeskunde, Universiteits-klinieken St. Rafaël Leuven, Belgium

The case of a young female patient suffering from Cushing's syndrome is described and discussed. Her adrenal pathology was characterized by the existence of multiple small adenomata, probably functional and independent of pituitary control. Clinically, removal of one gland followed by pituitary irradiation resulted in a disappearance of her symptomatology, except for a transient relapse coinciding with a successful pregnancy. One striking biochemical finding was a plasma cortisol binding capacity reduced to half the normal value.

¹ Address: Laboratorium voor Pathologische Ontleedkunde, Rijksuniversiteit Gent, Belgium.

² Present address: Section on Endocrinology, Laboratory of Experimental Surgery, University Clinics, St. Pierre, Leuven, Belgium.

Received August 4, 1964.

Accepted January 12, 1965.

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