This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via Google Scholar Google Scholar Articles by DAVIS, T. E. Articles by KORENMAN, S. G. Search for Related Content PubMed PubMed Citation Articles by DAVIS, T. E. Articles by KORENMAN, S. G.

Suppression of Testosterone Production by Physiologic Doses of 2-Methyldihydrotestosterone Propionate

The Endocrinology Branch, National Cancer Institute Bethesda, Maryland

Testosterone production rates in young men were measured during administration of a synthetic androgen, 2-methyldihydrotestosterone. At levels equivalent in androgenic potency to 8 mg of testosterone, production rates were decreased 27% in 5 days and 49% in 15 days. Higher doses induced almost complete suppression of testosterone production. The administration of human chorionic gonadotropin during the continued administration of androgens caused a prompt increase in testosterone production. It is concluded that physiologic doses of androgen can inhibit the secretion of interstitial cell-stimulating hormone.

Received August 12, 1964.

Accepted November 23, 1964.