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Occurrence of Dehydroisoandrosterone Glucuronoside in Normal Human Urine¹

Departments of Obstetrics and Gynecology and of Biochemistry, College of Physicians and Surgeons of Columbia University New York City

The isolation of dehydroisoandrosterone glucuronoside from normal human urine is described. When dehydroisoandrosterone was isolated from the urinary glucuronoside fraction after the administration of tritiated ehydroisoandrosterone, its specific activity was much larger than that of dehydroisoandrosterone isolated from the sulfate fraction. This indicates that the urinary sulfate is derived not only from dehydroisoandrosterone but also from the sulfate itself, which appears to be secreted by the adrenals.

This work was supported in part by Grants A-110 and A-1083 from the USPHS and NONR 266 (75).

¹ Taken in part from the Ph.D. dissertation of P. K. Siiteri, Columbia University, 1963.

² Present address: Department of Obstetrics and Gynecology, University of Texas, Southwestern Medical School, Dallas, Texas.

³ Career Scientist, Health Research Council, City of New York.

Received January 7, 1963.

Accepted March 5, 1963.

This article has been cited by other articles:

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