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Metabolism of Reichstein's Substance E in Man

Division of Steroid Metabolism and Biochemistry, Sloan-Kettering Institute for Cancer Research New York, N. Y.

The metabolism of Reichstein's Substance E-4-C¹⁴ (110,17,20β,21-tetrahydroxy- 4-pregnene-3-one) has been studied in a normal subject. It was found that 2 of the principal metabolic reactions, reduction of the 4-3-ketone and oxidation of the 11β- hydroxyl group, occurred with this hormone with a preformed glycerol side chain. No significant amounts of epimerization or oxidation of the 20β-hydroxyl group could be detected. The metabolic pattern observed after the administration of this compound was compared with that following hydrocortisone in the same subject. From these studies it was concluded that the reduction of the 20-keto group is not a major first step in the metabolism of hydrocortisone in normal man.

Received January 25, 1962.