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Testosterone Therapy of Male Eunuchoids III. Sublingual Administration of Testosterone Compounds

Department of Medicine, University of California Medical School San Francisco, California

AS STATED in the first paper of this series (1) entitled, ‘Implantation of testosterone compounds in cases of male eunuchoidisn’, "the effectiveness of an endocrine preparation is measured best by its capacity to restore normal function in a characteristic endocrinopathy caused by its deficiency. Eunuchoidism, or male hypogonadism, is the clinical state in which the primary deficiency resides in the testes, and therefore it represents an ideal clinical condition for testing the effectiveness of an androgenic substance."

The clinical efficacy of parenteral administration of testosterone propionate in the treatment of male eunuchoidism and of adult forms of male hypogonadism has been confirmed abundantly. For the past 4 or 5 years this testosterone preparation in oil has been available commercially. The effectiveness of implanting pellets of crystalline testosterone compounds, principally methyl testosterone, has been reported (1). It was demonstrated that in some respects the continuous absorption from such pellets was more efficient and presumably more economical than the injection of the hormone in oil, since only approximately one-fifth of the dose was required to obtain similar results.

Received May 25, 1942.

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