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Comparison of Metabolic Effects of Testosterone Propionate with Those of Chorionic Gonadotropin1^1,2,3

Departments of Medicine and Biochemistry of the University of Chicago Chicago, Illinois

IN A PREVIOUS communication we have noted that several of the metabolic effects of testosterone propionate in the adult eunuchoid could be observed in fairly well defined form with a dosage as low as 5 mg. daily (1, 2). This considerable sensitivity of the organism to the androgen is of great interest since such small amounts of testosterone propionate seem to fall well below requirements for replacement in adults, as nearly as these can be judged by repair of secondary sex characteristics and maintenance of normal urinary androgens (discussed in ref. I). Since many of these metabolic phenomena appear to be the chemical expressions of noivgenital tissue growth (3, 4) it becomes likely that the androgens may play a part in somatic growth at a time when the evolution of secondary sex characters is at least not conspicuous. Normally the boy's pubertal growth spurt is apparent some time before the appearance of axillary hair (5).

¹ The metabolic studies were supported by a grant from the Committee on Research in Endocrinology of the National Research Council.

² The urinary assays were made possible by a grant from the Committee for Research in Problems of Sex of the National Research Council, and by the Wallace C. and Clara A. Abbott Memorial Fund of the University of Chicago.

³ The testosterone propionate (Oreton) and chorionic gonadotropin (Pranturon) were provided by Dr. Erwin Schwenk and Dr. Max Gilbert of the Schering Co., Bloomfield, N. J.

Received September 8, 1942.

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