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PLASMA CORTISOL LEVELS IN MAN FOLLOWING ORAL AND INTRAVENOUS ADMINISTRATION OF CORTISOL^*

DENIS ABELSON, M.D., M.R.C.P. and D. A. BORCHERDS, B.Sc.

Department of Medicine, Postgraduate Medical School of London, Hammersmith Hospital London W 12, England

Plasma cortisol levels were determined at intervals following the administration of cortisol. After oral administration, the mean cortisol concentration reached a peak at one hour which was significantly higher in females. After intravenous administration, mean values were also higher in females than males, but this difference was not significant. Possible explanations for these findings are discussed.

^* Presented in part at the 64th meeting of the Society for Endocrinology, London, October 24, 1957. (Abelson, D., and Borcherds, D.: (abstract) J. Endocrinol. (London) 16: ix, 1958.)

Present address: Department of Internal Medicine, Yale University School of Medicine, 789 Howard Ave., New Haven, Connecticut, U.S.A.

Received May 26, 1958.