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ADRENOCORTICAL CARCINOMA IN MAN. THE EFFECT OF AMPHENONE ON INDIVIDUAL KETOSTEROIDS^*

Sloan-Kettering Institute for Cancer Research New York, N. Y.

Five patients with adrenocortical carcinoma were studied with respect to the production of various individual 17-ketosteroids during control periods and during treatment with amphenone (3,3-bis(p-aminophenyl)butanone-2). In all instances the drug caused a decrease in some or all of the steroid hormonemetabolites. A detailed discussion of each major component of the 17-ketosteroids leads to the conclusion that amphenone invariably lowers the production of hydrocortisone but exerts a variable influence upon other components of adrenal secretion. The results support the conclusion that the biosynthesis of adrenocortical hormones can be differentially altered, even in a neoplastic tissue.

^* This investigation was supported in part by a grant from the American Cancer Society and a research grant (CY-3207) from the National Cancer Institute of the National Institutes of Health, United States Public Health Service.

Received March 24, 1958.