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MYOTONIA ATROPHICA WITH TESTICULAR ATROPHY: URINARY EXCRETION OF INTERSTITIAL-CELL-STIMULATING (LUTEINIZING) HORMONE, ANDROGENS AND 17-KETOSTEROIDS^*

B. G. CLARKE, M.D., SUMNER SHAPIRO, M.D. and R. G. MONROE, M.D.

The Departments of Urology, Tufts University School of Medicine and the New England Center Hospital Boston, Massachusetts

The regular association of testicular atrophy and occasionally of other endocrine abnormalities with myotonia atrophica (dystrophia myotonica) has suggested that the disorder may represent a concatenated pluriglandular disturbance of endocrine origin and be susceptible to treatment by endocrine replacement therapy. An alternative interpretation is that myotonia atrophica, rather than reflecting a primary endocrine disturbance, is simply a manifestation of genetically linked degenerative phenomena seen in various tissues derived from embryonic ectoderm and mesoderm.

^* Aided by grants from the Charlton Research Fund, Tufts University School of Medicine and from the Trustees of the New England Center Hospital.

Associate Professor of Urology, Tufts University School of Medicine; Urologist, New England Center Hospital.

Lieutenant, junior grade, M. C., U.S.N.R.; formerly intern in medicine, New England Center Hospital.

Assistant Resident Physician, Boston City Hospital; formerly intern in medicine, New England Center Hospital.

Received December 31, 1955.