THE SYNDROME OF FAMILIAL JUVENILE HYPOADRENOCORTICISM, HYPOPARATHYROIDISM AND SUPERFICIAL MONILIASIS
JoANNE WHITAKER, M.D.*,
BENJAMIN H. LANDING, M.D.,
VIRGINIA M. ESSELBORN, M.D. and
ROBERT R. WILLIAMS, M.D.
The Departments of Pediatrics and Pathology of The Children's Hospital and Children's Hospital Research Foundation, the Departments of Pediatrics, Pathology and Internal Medicine of the University of Cincinnati College of Medicine, and the Department of Pathology of the Middletown Hospital Middletown, Ohio
The coincidence of hypoparathyroidism and Addison's diseasein children is rare, only 7 cases being found in the availableliterature (1–9). The present paper surveys this materialbriefly and presents an additional patient with hypoadrenocorticismand hypoparathyroidism—a 15-year-old boy studied at TheCincinnati Children's Hospital, in whom the clinical diagnoseswere confirmed by autopsy findings. From these data, evidenceindicating that the syndrome in question has in general thefeatures of "familial juvenile hypoadrenocorticism, hypoparathyrodismand superficial moniliasis" has been assembled, and the suggestionoffered that other reported cases with some of these featuresare incomplete examples of the syndrome. Relationships betweenthe monilial infection and the endocrine dysfunctions, and otherimplications of this syndrome, are also discussed.
* Present address: Memorial Hospital, Memorial Center for Cancer,and Allied Diseases, 444 East 68th Street, New York 21, N. Y.
Received January 23, 1956.
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