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DOSAGE OF METHYLTESTOSTERONE

H. LISSER, M.D.^*, ROBERTO F. ESCAMILLA, M.D. and GILBERT S. GORDAN, M.D.

Endocrine Clinic, Department of Medicine, University of California School of Medicine San Francisco 22, California

In the Journal of Clinical Endocrinology and Metabolism 13: 235 (Feb.). 1953, Doctor Carl Heller is quoted as stating that the dose of methyltestosterone given sublingually or buccally for the management of male eunuchoidism is 40 to 80 mg. per day. This is contrary to our experience, which has been that doses over 40 mg. per day can rarely be given such patients by the sublingual or buccal route without the production of symptoms of overdosage, viz., priapism, edema, or gynecomastia. In over 40 hypogonadal patients followed in this clinic we have found it possible to initiate improvement with doses of 20 to 40 mg. per day and to maintain all the patients by the administration of 10 to 20 mg. of methyltestosterone daily, given by the sublingual or buccal route. The first 12 such patients were reported by Escamilla and Gordan (Efficacy of Testosterone Compounds Administered Sublingually to Hypogonadal Men, J. Clin. Endocrinol. 10: 248–264 (Feb.) 1950). Indeed, an occasional patient has been observed who demonstrates full androgenic effects on as little as 5 mg. of methyltestosterone, sublingually or buccally, per day.

^* Clinical Professor of Medicine & Endocrinology

Associate Clinical Professor of Medicine

Assistant Professor of Medicine