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THE MECHANISM RESPONSIBLE FOR THE ALTERED BLOOD CHOLESTEROL CONTENT IN DERANGED THYROID STATES^*,

Mount Zion Hospital, The Harold Brunn Institute San Francisco, California

I. INTRODUCTION: ALTHOUGH it is almost thirty years since abnormalities of blood cholesterol content were observed to follow deranged thyroid activity (1), the mechanism responsible for these changes remains unknown. Moreover, the obscurity surrounding this interesting thyroid-blood cholesterol relationship has persisted, despite the clinical recognition (2) of a possible association between the hypercholesteremia of the hypothyroid state and the premature atherosclerosis believed by many to occur in this disease.

It appeared important to investigate some of the underlying processes concerned with the altered blood cholesterol level in both the hyperthyroid and hypothyroid states. By using various new techniques we have been able to discover that the underlying fault in cholesterol metabolism in the hyperthyroid state is one in which an increase occurs, not only in the rate of manufacture, but also in the rate of excretion and destruction of cholesterol. We have also found that, conversely, the same processes are slowed in the hypothyroid state.

^* First Honorable Mention, Van Meter Prize Award essay.

This article will be included in the bound volume of the 1952 "Transactions of the American Goiter Association" published by Charles C Thomas, Publisher, which will be available for sale early in 1953.

Aided by grants from the American Heart Association and the United States Public Health Service.

Received May 31, 1952.

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